The binding of benzenesulfonamides to carbonic anhydrase enzyme. A molecular mechanics study and quantitative structure-activity relationships.

نویسندگان

  • M C Menziani
  • P G De Benedetti
  • F Gago
  • W G Richards
چکیده

Molecular mechanics methods have been applied to study the interaction between a series of 20 deprotonated benzenesulfonamides and the enzyme carbonic anhydrase. The different contributions to the binding energy have been evaluated and correlated with experimental inhibition data and molecular orbital indices of the sulfonamides in their bound conformation. The results suggest that the discrimination shown by the enzyme toward these inhibitors is dominated by the short-range van der Waals forces.

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عنوان ژورنال:
  • Journal of medicinal chemistry

دوره 32 5  شماره 

صفحات  -

تاریخ انتشار 1989